With the advancement of pharmaceutical technology, numerous challenges arise in applying the traditional paddle-basket dissolution method to test new types of medicines such as microspheres, stents, or implants. However, as a new technology, the flow-through cell dissolution method has unique open/close loop work modes that can better simulate the environment of human bodies and solve the problems faced when testing the dissolution/releasing rate of special medicines (such as medicines that are hard to dissolve or are in small dosages). In recent years, the Flow-Through Cell Dissolution System has become crucial for the research and development, as well as the quality control, of new extended-release formulations and delayed-release formulations.
FACT-701H Flow-Through Cell Dissolution System is independently developed and manufactured by FOCS. It is characterized by its simple structure and powerful functionality, allowing it to conduct seven channels of separated open/close loop dissolution experiments. This system plays a significant role in the research and development of extended-release formulations, delayed-release formulations, and other special formulations.
System parameters and performance in accordance with CP and USP.
Two-piece structure, enabling switch between open-loop and close-loop dissolution modes.
Automatic flow-through cell rack, capable of completing rising, descending, sealing, and filling with one click.
Imported high-precision ceramic pump, providing a flow rate of 2-32 ml/min and a pulse flow mode of 120 Hz, in accordance with the requirements of USP.
Seven built-in high-precision pressure sensors, monitoring the pressure of each channel in real-time and starting protection mode in the event of detecting abnormal conditions.
Various custom-made cells, meeting the experimental requirements of various types of formulations.
Imported PTFE tubes and PEEK control valves with excellent anti-absorption performance.
Seven by thirty test tubes (10ml) tray and liquid phase vials (1.5ml) tray, capable of consecutively collecting samples for 30 times.
High-precision sampling pumps and a low-temperature pre-heat module, guaranteeing precise sampling in low-temperature environments.
Multi-level authorized management system and real-time operation record, fulfilling the requirements of audit trail and ensuring the intactness of the digital records.
Optional built-in camera system, enabling online monitoring on mobile phones.
Featuring a two-piece structure, simple and user-friendly.
Enabling one-touch switching between open and closed-loop modes, eliminating the need for cumbersome manual operations during traditional mode transitions.
Automatically raising and lowering the flow-through cell rack, with one-touch controls for elevation, sealing, and filling.
Automatically raising and lowering the liquid withdrawal needle and sampling needle rack, facilitating one-touch execution of integrated open and closed-loop tests as well as cleaning.
Equipped with high-precision pressure sensors for real-time monitoring of channel status.
Utilizing two sets of high-precision weighing sensors for automatic calibration of flow rate deviations.
Incorporating an integrated high-definition camera system for automatic recording and storage of the dissolution process, with the capability to export and enable remote real-time monitoring.
Providing a reserved fiber optic interface for potential upgrades to fiber optic online real-time testing mode, facilitating easier access to the entire dissolution process (such as the Cmax point).
